Роль кишечного микробиома в патогенезе эндометриоза: механизмы взаимодействия и терапевтические перспективы

1. Crump J., Suker A., White L. Endometriosis: A review of recent evidence and guidelines. Aust. J. Gen. Pract. 2024; 53(1-2):11-8. https://dx.doi.org/10.31128/AJGP/04-23-6805
2. Adilbayeva A., Kunz J. Pathogenesis of endometriosis and endometriosis-associated cancers. Int. J. Mol. Sci. 2024; 25(14): 7624. https://dx.doi.org/10.3390/ijms25147624
3. Hämisch B., Büngeler A., Kielar C., Keller A., Strube O., Huber K. Self-assembly of fibrinogen in aqueous, thrombin-free solutions of variable ionic strengths. Langmuir. 2019; 35(37): 12113-22. https://dx.doi.org/10.1021/acs.langmuir.9b01515
4. Табеева Г.И., Думановская М.Р., Чернуха Г.Е., Припутневич Т.В. Современные представления о микробиоте в гинекологии. Акушерство и гинекология. 2020; 2: 38-44. https://dx.doi.org/10.18565/aig.2020.2. 38-44 [Tabeeva G.I., Dumanovskaya M.R., Chernukha G.E., Priputnevich T.V. Current views on microbiota in gynecology. Obstetrics and Gynecology. 2020; (2): 38-44 (in Russian). https://dx.doi.org/10.18565/aig.2020.2.38-44].
5. Cuffaro F., Russo E., Amedei A. Endometriosis, pain, and related psychological disorders: Unveiling the interplay among the microbiome, inflammation, and oxidative stress as a common thread. Int. J. Mol. Sci. 2024; 25(12): 6473. https://dx.doi.org/10.3390/ijms25126473
6. Jiang I., Yong P.J., Allaire C., Bedaiwy M.A. Intricate connections between the microbiota and endometriosis. Int. J. Mol. Sci. 2021; 22(11): 5644. https://dx.doi.org/10.3390/ijms22115644
7. Ярмолинская М.И., Русина Е.И., Семенова В.О., Беганова А.К. Экстрагенитальный эндометриоз: сложности диагностики, современная тактика лечения. Акушерство и гинекология. 2022; 8: 154-62. https://dx.doi.org/10.18565/aig.2022.8.154-162 [Yarmolinskaya M.I., Rusina E.I., Semenova V.O., Beganova A.K. Extragenital endometriosis: diagnostic difficulties, modern treatment policy. Obstetrics and Gynecology. 2022; (8): 154-12 (in Russian). https://dx.doi.org/10.18565/aig.2022.8.154-162].
8. Shen H.H., Zhang T., Yang H.L., Lai Z.Z., Zhou W.J., Mei J. et al. Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis. Theranostics. 2021; 11(7): 3512-26. https://dx.doi.org/10.7150/thno.55241
9. Horne A.W., Missmer S.A. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022; 379: e070750. https://dx.doi.org/10.1136/bmj-2022-070750
10. Raman K., Siegert R.J., Bharatharaj J., Krägeloh C.U. Validation of a Tamil Version of the Five Facet Mindfulness Questionnaire Using Rasch Analysis. Indian J. Psychol. Med. 2024; 46(2): 147-58. https://dx.doi.org/10.1177/02537176231220564
11. Zizolfi B., Foreste V., Gallo A., Martone S., Giampaolino P., Di Spiezio Sardo A. Endometriosis and dysbiosis: State of art. Front. Endocrinol (Lausanne). 2023; 14: 1140774. https://dx.doi.org/10.3389/fendo.2023.1140774
12. Giacomini E., Minetto S., Li Piani L., Pagliardini L., Somigliana E., Viganò P. Genetics and inflammation in endometriosis: improving knowledge for development of new pharmacological strategies. Int. J. Mol. Sci. 2021; 22(16): 9033. https://dx.doi.org/10.3390/ijms22169033
13. Pašalić E., Tambuwala M.M., Hromić-Jahjefendić A. Endometriosis: Classification, pathophysiology, and treatment options. Pathol. Res. Pract. 2023; 251: 154847. https://dx.doi.org/10.1016/j.prp.2023.154847
14. Hon J.X., Wahab N.A., Karim A.K.A., Mokhtar N.M., Mokhtar M.H. MicroRNAs in endometriosis: insights into inflammation and progesterone resistance. Int. J. Mol. Sci. 2023; 24(19): 15001. https://dx.doi.org/10.3390/ijms241915001
15. Maddern J., Grundy L., Castro J., Brierley S.M. Pain in endometriosis. Front. Cell. Neurosci. 2020; 14: 590823. https://dx.doi.org/10.3389/fncel.2020.590823
16. Manos J. The human microbiome in disease and pathology. APMIS. 2022; 130(12): 690-705. https://dx.doi.org/10.1111/apm.13225
17. Martin-Gallausiaux C., Marinelli L., Blottière H.M., Larraufie P., Lapaque N. SCFA: mechanisms and functional importance in the gut. Proc. Nutr. Soc. 2021; 80(1): 37-49. https://dx.doi.org/10.1017/S0029665120006916
18. Di Tommaso N., Gasbarrini A., Ponziani F.R. Intestinal barrier in human health and disease. Int. J. Environ. Res. Public Health. 2021; 18(23): 12836. https://dx.doi.org/10.3390/ijerph182312836
19. Yan J.B., Luo M.M., Chen Z.Y., He B.H. The function and role of the Th17/Treg cell balance in inflammatory bowel disease. J. Immunol. Res. 2020; 2020: 8813558. https://dx.doi.org/10.1155/2020/8813558
20. Sisnett D.J., Zutautas K.B., Miller J.E., Lingegowda H., Ahn S.H., McCallion A. et al. The dysregulated IL-23/TH17 axis in endometriosis pathophysiology. J. Immunol. 2024; 212(9): 1428-41. https://dx.doi.org/10.4049/jimmunol.2400018
21. Di Vincenzo F., Del Gaudio A., Petito V., Lopetuso L.R., Scaldaferri F. Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Intern. Emerg. Med. 2024; 19(2): 275-93. https://dx.doi.org/10.1007/s11739-023-03374-w
22. Kinashi Y., Hase K. Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity. Front. Immunol. 2021; 12: 673708. https://dx.doi.org/10.3389/fimmu.2021.673708
23. Martel J., Chang S.H., Ko Y.F., Hwang T.L., Young J.D., Ojcius D.M. Gut barrier disruption and chronic disease. Trends Endocrinol. Metab. 2022; 33(4): 247-65. https://dx.doi.org/10.1016/j.tem.2022.01.002
24. Qi X., Yun C., Pang Y., Qiao J. The impact of the gut microbiota on the reproductive and metabolic endocrine system. Gut Microbes. 2021; 13(1): 1-21. https://dx.doi.org/10.1080/19490976.2021.1894070
25. Чернуха Г.Е., Пронина В.А., Припутневич Т.В. Микробиота кишечника и репродуктивного тракта при эндометриозе. Акушерство и гинекология. 2022; 8: 22-9. https://dx.doi.org/10.18565/aig.2022.8.22-29 [Chernukha G.E., Pronina V.A., Priputnevich T.V. Gut and genital microbiota in endometriosis. Obstetrics and Gynecology. 2022; (8): 22-9 (in Russian). https://dx.doi.org/10.18565/aig.2022.8.22-29].
26. Aragón A., Jurado R., Jara J., Rodríguez J.M., Orgaz B. Investigating the Metabolism of estrogens in Ligilactobacillus salivarius strains isolated from human milk and vaginal microbiota. Nutrients. 2024; 16(6): 861. https://dx.doi.org/10.3390/nu16060861
27. Baușic A.I.G., Scurtu F., Manu A., Matasariu D.R., Brătilă E. Gut microbiota dysbiosis in endometriosis: a potential link to inflammation and disease progression. Int. J. Mol. Sci. 2025; 26(11): 5144. https://dx.doi.org/10.3390/ijms26115144
28. Hu S., Ding Q., Zhang W., Kang M., Ma J., Zhao L. Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism. Gut Microbes. 2023; 15(1): 2236749. https://dx.doi.org/10.1080/19490976.2023.2236749
29. Le N., Cregger M., Brown V., Loret de Mola J., Bremer P., Nguyen L. et al. Association of microbial dynamics with urinary estrogens and estrogen metabolites in patients with endometriosis. PLoS One. 2021; 16(12): e0261362. https://dx.doi.org/10.1371/journal.pone.0261362
30. Green T., See J., Schauch M., Reil J., Glover M., Brix J. et al. A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense®on 2-hydroxyestrone:16α-hydroxyestrone ratio in premenopausal women. J. Complement. Integr. Med. 2022; 20(1): 199-206. https://dx.doi.org/10.1515/jcim-2022-0301
31. Tatullo M., Nor J., Orrù G., Piattelli A., Cascardi E., Spagnuolo G. Oral-gut-estrobolome axis may exert a selective impact on oral cancer. J. Dent. Res. 2024; 103(5): 461-6. https://dx.doi.org/10.1177/00220345241236125
32. Fritsch J., Garces L., Quintero M.A., Pignac-Kobinger J., Santander A.M., Fernández I. et al. Low-fat, high-fiber diet reduces markers of inflammation and dysbiosis and improves quality of life in patients with ulcerative colitis. Clin. Gastroenterol. Hepatol. 2021; 19(6): 1189-1199.e30. https://dx.doi.org/10.1016/j.cgh.2020.05.026
33. Vennberg Karlsson J., Patel H., Premberg A. Experiences of health after dietary changes in endometriosis: a qualitative interview study. BMJ Open. 2020; 10(2): e032321. https://dx.doi.org/10.1136/bmjopen-2019-032321
34. Barnard N.D., Holtz D.N., Schmidt N., Kolipaka S., Hata E., Sutton M. et al. Nutrition in the prevention and treatment of endometriosis: A review. Front. Nutr. 2023; 10: 1089891. https://dx.doi.org/10.3389/fnut.2023.1089891
35. Nirgianakis K., Egger K., Kalaitzopoulos D.R., Lanz S., Bally L., Mueller M.D. Effectiveness of dietary interventions in the treatment of endometriosis: A systematic review. Reprod. Sci. 2022; 29(1): 26-42. https://dx.doi.org/10.1007/s43032-020-00418-w
36. Schwartz N.R.M., Afeiche M.C., Terry K.L., Farland L.V., Chavarro J.E., Missmer S.A. et al. Glycemic index, glycemic load, fiber, and gluten intake and risk of laparoscopically confirmed endometriosis in premenopausal women. J. Nutr. 2022; 152(9): 2088-96. https://dx.doi.org/10.1093/jn/nxac107
37. Kamal D.A.M., Salamt N., Yusuf A.N.M., Kashim M.I.A.M., Mokhtar M.H. Potential health benefits of curcumin on female reproductive disorders: A review. Nutrients. 2021; 13(9): 3126. https://dx.doi.org/10.3390/nu13093126
38. Vallée A., Lecarpentier Y. Curcumin and endometriosis. Int. J. Mol. Sci. 2020; 21(7): 2440. https://dx.doi.org/10.3390/ijms21072440
39. Cao F., Jin L., Gao Y., Ding Y., Wen H., Qian Z. et al. Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis. Nat. Nanotechnol. 2023; 18(6): 617-27. https://dx.doi.org/10.1038/s41565-023-01346-x
40. Yalçın Bahat P., Ayhan I., Üreyen Özdemir E., İnceboz Ü., Oral E. Dietary supplements for treatment of endometriosis: A review. Acta Biomed. 2022; 93(1): e2022159. https://dx.doi.org/10.23750/abm.v93i1.11237
41. Molina N.M., Sola-Leyva A., Saez-Lara M.J., Plaza-Diaz J., Tubić-Pavlović A., Romero B. et al. New opportunities for endometrial health by modifying uterine microbial composition: Present or Future? Biomolecules. 2020; 10(4): 593. https://dx.doi.org/10.3390/biom10040593
42. Qin R., Tian G., Liu J., Cao L. The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment. Front. Cell. Infect. Microbiol. 2022; 12: 1069557. https://dx.doi.org/10.3389/fcimb.2022.1069557
43. Jiang I., Yong P.J., Allaire C., Bedaiwy M.A. Intricate connections between the microbiota and endometriosis. Int. J. Mol. Sci. 2021; 22(11): 5644. https://dx.doi.org/10.3390/ijms22115644
44. Talwar C., Singh V., Kommagani R. The gut microbiota: a double-edged sword in endometriosis. Biol. Reprod. 2022; 107(4): 881-901. https://dx.doi.org/10.1093/biolre/ioac147
45. Brennan C., Chan K., Kumar T., Maissy E., Brubaker L., Dothard M.I. et al. Harnessing the power within: engineering the microbiome for enhanced gynecologic health. Reprod. Fertil. 2024; 5(2): e230060. https://dx.doi.org/10.1530/RAF-23-0060
46. Chadchan S.B., Popli P., Ambati C.R., Tycksen E., Han S.J., Bulun S.E. et al. Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis. Life Sci. Alliance. 2021; 4(12): e202101224. https://dx.doi.org/10.26508/lsa.202101224
47. Kim N., Yang C. Butyrate as a potential modulator in gynecological disease progression. Nutrients. 2024; 16(23): 4196. https://dx.doi.org/10.3390/nu16234196
48. Shi Y., Wang G., Lau H.C., Yu J. Metagenomic sequencing for microbial DNA in human samples: Emerging technological advances. Int. J. Mol. Sci. 2022; 23(4): 2181. https://dx.doi.org/10.3390/ijms23042181
49. Hantsoo L., Zemel B.S. Stress gets into the belly: Early life stress and the gut microbiome. Behav. Brain Res. 2021; 414: 113474. https://dx.doi.org/10.1016/j.bbr.2021.113474
50. Aruchunan M., Nivethitha L. Yoga may help to reduce gut microbiota dysbiosis in rheumatoid arthritis: A hypothesis. Int. J. Rheum. Dis. 2023; 26(10): 1908-10. https://dx.doi.org/10.1111/1756-185X.14589

Поступила 19.03.2026

Принята в печать 06.07.2026

Received 19.03.2026

Accepted 06.07.2026