Влияние эндогенного тестостерона на здоровье и качество жизни у женщин в постменопаузе
Ермакова Е.И., Сметник А.А.
Согласно статистическим прогнозам, к 2050 г. 30% мирового населения достигнут возраста 65 лет и более. Увеличение продолжительности жизни сопровождается ростом числа лет, прожитых с хроническими и возраст-ассоциированными заболеваниями. У женщин в постменопаузе на фоне эстрогенодефицита возрастает риск развития ожирения, инсулинорезистентности, сахарного диабета 2 типа, сердечно-сосудистых осложнений. Роль андрогенов в развитии возраст-ассоциированных заболеваний до недавнего времени оставалась неопределенной. Последние литературные данные свидетельствуют о том, что эндогенные андрогены оказывают протективные эффекты на сердечно-сосудистую систему, когнитивные функции, костно-мышечную систему и либидо у женщин в постменопаузе. В связи с этим важно рационально подбирать менопаузальную гормонотерапию с учетом сохранения физиологического уровня эндогенных гормонов, в том числе андрогенов.
Заключение: При ведении женщин в постменопаузе ключевым аспектом становится персонализированный подход, учитывающий индивидуальные особенности пациентки. Менопаузальная гормональная терапия, не подавляющая продукцию эндогенных андрогенов, в комплексе с коррекцией образа жизни – ключ к здоровому долголетию и улучшению качества жизни женщин в постменопаузе.
Вклад авторов: Ермакова Е.И., Сметник А.А. – концепция и дизайн, сбор и обработка материала, написание текста, редактирование.
Конфликт интересов: Авторы заявляют об отсутствии конфликта интересов.
Финансирование: Исследование не имело спонсорской поддержки.
Для цитирования: Ермакова Е.И., Сметник А.А. Влияние эндогенного тестостерона на
здоровье и качество жизни у женщин в постменопаузе.
Акушерство и гинекология. 2025; 6: 74-82
https://dx.doi.org/10.18565/aig.2025.161
Ключевые слова
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Поступила 18.06.2025
Принята в печать 25.06.2025
Об авторах / Для корреспонденции
Ермакова Елена Ивановна, к.м.н., с.н.с. отделения гинекологической эндокринологии, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Ак. Опарина, д. 4; вице-президент Российского общества специалистов по гинекологической эндокринологии и менопаузе, +7(916)848-37-46, e_ermakova@oparina4.ru, https://orcid.org/0000-0002-6629-051XСметник Антонина Александровна, к.м.н., заведующая отделением гинекологической эндокринологии, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Академика Опарина, д. 4; президент Российского общества специалистов по гинекологической эндокринологии и менопаузе, +7(495)531-44-44, a_smetnik@oparina4.ru, https://orcid.org/0000-0002-0627-3902