Текущий прогресс генетических и эпигенетических исследований детского церебрального паралича
Детский церебральный паралич (ДЦП) является гетерогенным состоянием, общей чертой которого является непрогрессирующая дисфункция движения и позы. Несмотря на широкое изучение, этиология ДЦП пока не понята. Считается, что в большинстве случаев ДЦП возникает вследствие внутриутробного повреждения развивающегося мозга. Всё больше данных свидетельствуют о том, что (эпи)генетические факторы могут в сумме отвечать за большое число случаев ДЦП. В этом мини-обзоре мы сосредоточимся в основном на генетических и эпигенетических аспектах последних достижений в понимании этиологии ДЦП.Чэнь Шен, Нанберт Чжун
Ключевые слова
мини-обзор
детский церебральный паралич
этиология
генетика
эпигенетика
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Дата поступления 20.12.2018
Дата принятия в печать 22.02.2019
Об авторах / Для корреспонденции
Чэнь Шен, PhD, Пекинский педиатрический научно-исследовательский институт, Пекинская Детская больница, Столичный медицинский университет, Национальный центр охраны здоровья детей, 56 НАН-л-и-сХай Роуд , Пекин 10045, Китай, тел.: +861059616983. Электронная почта: shenchen1110@126.com.Нанберт Чжун, MD, Институт фундаментальных исследований штата Нью-Йорк по инвалидности в области развития, 1050 Форест-Хилл-роуд, Статен-Айленд, NY 10314, США. Тел/Факс: (01) 7184945242/4882. Электронная почта: Nanbert.Zhong@opwdd.ny.gov
Для цитирования: Чэнь Шен, Нанберт Чжун. Текущий прогресс генетических и эпигенетических исследований детского церебрального паралича. Акушерство и гинекология. 2019; 6:94-101.
https://dx.doi.org/10.18565/aig.2019.6.94-101