Перспективы лечения бесплодия методами вспомогательных репродуктивных технологий у женщин старше 40 лет с собственными ооцитами
В настоящее время деторождение у женщин позднего репродуктивного возраста является не только актуальной клинической, но и социальной проблемой. Патогенез бесплодия у супружеских пар данной возрастной группы крайне сложен, представлен сочетанием нескольких факторов и часто требует персонализированного подхода к лечению.Хачатрян Л.В., Макарова Н.П., Калинин А.П., Смольникова В.Ю.
В обзоре представлены данные о роли генетических факторов и сигнальных путей оксидативного стресса в реализации патогенетических механизмов старения яичников. Проведен обзор различных протоколов контролируемой стимуляции яичников и подходов к оптимизации программ вспомогательных репродуктивных технологий у пациенток позднего репродуктивного возраста. Представлена информация об экспериментальных исследованиях, которая позволит расширить понимание о перспективах лечения бесплодия у пациенток изучаемой возрастной когорты.
Заключение: Изучение патогенетических механизмов старения яичников является одним из ключевых направлений оптимизации программ лечения бесплодия у женщин позднего репродуктивного возраста методами ВРТ с собственными ооцитами, а также представляет научный интерес для разработки в будущем инновационных терапевтических подходов для данной когорты пациенток.
Ключевые слова
вспомогательные репродуктивные технологии (ВРТ)
оптимизация программ ВРТ
поздний репродуктивный возраст
оксидативный стресс
сигнальные пути
старение яичников
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Поступила 07.02.2023
Принята в печать 29.03.2023
Об авторах / Для корреспонденции
Хачатрян Лия Варужановна, аспирантка кафедры акушерства, гинекологии, перинатологии и репродуктологии ИПО, Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет), +7(963)977-88-94, leahkhachatryan@gmail.com, https://orcid.org/0000-0003-4867-500X,119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2.
Макарова Наталья Петровна, д.б.н., в.н.с. отделения вспомогательных технологий в лечении бесплодия им. проф. Б.В. Леонова, НМИЦ АГП им. академика В.И. Кулакова Минздрава России, np_makarova@oparina4.ru, https://orcid.org/0000-0003-8922-2878, 117997, Россия, Москва, ул. Академика Опарина, д. 4.
Калинин Андрей Павлович, студент лечебного факультета, РНИМУ им. Н.И. Пирогова Минздрава России, +7(985)157-78-31, zoaza8@mail.ru, 117997, Россия, Москва, ул. Островитянова, д. 1.
Смольникова Вероника Юрьевна, д.м.н., доцент, в.н.с. отделения вспомогательных технологий в лечении бесплодия им. проф. Б.В. Леонова, НМИЦ АГП им. академика В.И. Кулакова Минздрава России, v_smolnikova@oparina4.ru, 117997, Россия, Москва, ул. Академика Опарина, д. 4.
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