Формирование биопленок условно-патогенными микроорганизмами, выделенными из вагинального биотопа

1. Радзинский В.Е., Савичева А.М., ред. Биоценоз влагалища. Норма. Нарушения. Восстановление. М.: Редакция журнала Status Praesens; 2023. 360 с. https://dx.doi.org/10.29039/978-5-907218-72-7 [Radzinsky V.E., Savicheva A.M., eds. Vaginal biocenosis. Standard. Violations. Restoration. Moscow: Editorial Board of the Status Praesens journal; 2023. 360 p. (in Russian). https://dx.doi.org/10.29039/978-5-907218-72-7].
2. Зайцев А.В., Аполихина И.А., Ходырева Л.А., Берников А.Н., Куприянов Ю.А., Строганов Р.В., Арефьева О.А., Тетерина Т.А. Роль нарушения микробиоты влагалища в патогенезе рецидивирующей инфекции нижних мочевыводящих путей: современный взгляд на проблему. Акушерство и гинекология. 2021; 5: 40-6. https://dx.doi.org/10.18565/aig.2021.5.40-46 [Zaitsev A.V., Apolikhina I.A., Khodyreva L.A., Bernikov A.N., Kupriyanov Yu.A., Stroganov R.V., Arefyeva O.A., Teterina T.A. Role of abnormal vaginal microbiota in the pathogenesis of recurrent lower urinary tract infection: a modern view of the problem. Obstetrics and Gynecology. 2021; (5): 40-6 (in Russian). https://dx.doi.org/10.18565/aig.2021.5.40-46].
3. Доброхотова Ю.Э., Маркова Э.А. Смешанный вагинит в современных условиях: особенности течения и выбор подходов к лечению. Проблемы репродукции. 2022; 28(4): 137-44. https://dx.doi.org/10.17116/repro202228041137 [Dobrokhotova Yu.E., Markova E.A. Mixed vaginitis. What's new? Features of the course and therapy of mixed vaginitis. Russian Journal of Human Reproduction. 2022; 28(4): 137-44 (in Russian). https://dx.doi.org/10.17116/repro202228041137].
4. Ильина Т.С., Романова Ю.М. Бактериальные биопленки: роль в хронических инфекционных процессах и поиск средств борьбы с ними. Молекулярная генетика, микробиология и вирусология. 2021; 39(2): 14 24. https://dx.doi.org/10.17116/molgen20213902114 [Ilyina T.S., Romanova Yu. M. Bacterial biofilms: their role in chronical infection processes and the means to combat them. Molecular Genetics, Microbiology and Virology. 2021; 39(2): 14-24. (in Russian). https://dx.doi.org/10.17116/molgen20213902114].
5. Нурузова З.А., Байматов Р.А., Толипова Г.К. Биопленка микроорганизмов – апробированные методы исследования. Биология и интегративная медицина. 2019; 3(31): 5-17. [Nuruzova Z.A., Baimatov R.A., Tolipova G.K. Microbial biofilm – proven research methods. Biology and Integrative Medicine. 2019; 3(31): 5-17 (in Russian)].
6. Шалепо К.В., Спасибова Е.В., Крысанова А.А, Хуснутдинова Т.А., Будиловская О.В., Сторожева К.В, Тапильская Н.И., Савичева А.М., Коган И.Ю. Сравнение методов выявления биопленочного синдрома при бактериальном вагинозе. Акушерство и гинекология. 2025; 7: 121-9. https://doi.org/10.18565/aig.2025.117 [Shalepo K.V.,Spasibova E.V., Krysanova A.A., Khusnutdinova T.A., Budilovskaya O.V., Storozheva K.V., Tapilskaya N.I., Savicheva A.M., Kogan I.Yu. Comparison of methods for detecting biofilm syndrome in bacterial vaginosis. Obstetrics and Gynecology. 2025; (7): 121-9 (in Russian). https://dx.doi.org/10.18565/aig.2025.117].
7. Rather M.A., Gupta K., Mandal M. Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies. Braz. J. Microbiol. 2021; 52(4): 1701-18. https://doi.org/10.1007/s42770-021-00624-x
8. Jamal M., Ahmad W., Andleeb S., Jalil F., Imran M., Nawaz M.A. et al. Bacterial biofilm and associated infections. J. Chin. Med. Assoc. 2018; 81(1): 7-11. https://doi.org/10.1016/j.jcma.2017.07.012
9. Хрянин А.А. Биопленки микроорганизмов: современные представления. Антибиотики и Химиотерапия. 2020; 65(5-6): 70-7. https://dx.doi.org/10.37489/0235-2990-2020-65-5-6-70-77 [Khryanin A.A. Microbial biofilms: modern concepts. Antibiotics and Chemotherapy. 2020; 65(5-6): 70-7 (in Russian). https://dx.doi.org/10.37489/0235-2990-2020-65-5-6-70-77].
10. Zhao X., Yu Z., Ding T. Quorum-sensing regulation of antimicrobial resistance in bacteria. Microorganisms. 2020; 8(3): 425. https://dx.doi.org/10.3390/microorganisms8030425
11. Parolin C., Croatti V., Giordani B., Vitali B. Vaginal Lactobacillus impair Candida dimorphic switching and biofilm formation. Microorganisms. 2022; 10(10): 2091. https://dx.doi.org/10.3390/microorganisms10102091
12. Arias Valverde J., Alvarado Fernández M.L., Alvarado Mora M.L., Arias Alvarado M.J., Vanegas Navarro P. Probiotics as a preventive strategy for recurrent bacterial vaginosis: a narrative review. Cureus. 2025; 17(8): e89764. https://dx.doi.org/10.7759/cureus.89764
13. Verstraelen H., Swidsinski A. The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment: 2018 update. Curr. Opin. Infect. Dis. 2019; 32(1): 38-42. https://dx.doi.org/10.1097/QCO.0000000000000516
14. Qin H., Liu Y., Zhai Z., Xiao B. Biofilm-forming capacity and drug resistance of different Gardnerella subgroups associated with bacterial vaginosis. Microorganisms. 2023; 11(9): 2186. https://dx.doi.org/10.3390/microorganisms11092186
15. Faustino M., Ferreira C.M.H., Pereira A.M., Carvalho A.P. Candida albicans: the current status regarding vaginal infections. Appl. Microbiol. Biotechnol. 2025; 109(1): 91. https://dx.doi:10.1007/s00253-025-13478-2
16. Mohammadi F., Hemmat N., Bajalan Z., Javadi A. Analysis of biofilm-related genes and antifungal susceptibility pattern of vaginal Candida albicans and non-Candida albicans species. Biomed. Res. Int. 2021; 2021: 5598907. https://dx.doi.org/10.1155/2021/5598907
17. Rodríguez-Cerdeira C., Gregorio M.C., Molares-Vila A., López-Barcenas A., Fabbrocini G., Bardhi B. et al. Biofilms and vulvovaginal candidiasis. Colloids Surf. B Biointerfaces. 2019; 174: 110-125. https://dx.doi.org/10.1016/j.colsurfb.2018.11.011
18. Ma X., Wu M., Wang C., Li H., Fan A., Wang Y., Han C., Xue F. The pathogenesis of prevalent aerobic bacteria in aerobic vaginitis and adverse pregnancy outcomes: a narrative review. Reprod. Health. 2022; 19: 21. https://dx.doi.org/10.1186/s12978-021-01292-8
19. Mahale R.P. K. A., Princy A., Maheshwarappa Y.D., Sumana M.N. Comparative evaluation of biofilm-forming capacity in uropathogenic and commensal Escherichia coli. Front. Cell. Infect. Microbiol. 2025; 15: 1570422. https://dx.doi.org/10.3389/fcimb.2025.1570422
20. Tamrat E., Asmare Z., Geteneh A., Sisay A., Getachew E., Kassanew B. et al. The global prevalence of biofilm-forming Enterococcus faecalis in clinical isolates: a systematic review and meta-analysis. BMC Infect. Dis. 2025; 25(1): 981. https://dx.doi.org/10.1186/s12879-025-11399-z
21. Kaminska D., Ratajczak M., Szumała-Kąkol A., Dlugaszewska J., Nowak-Malczewska D.M., Gajecka M. Increasing resistance and changes in distribution of serotypes of Streptococcus agalactiae in Poland. Pathogens. 2020; 9(7): 526. https://dx.doi.org/10.3390/pathogens9070526
22. Shang X., Bai H., Fan L., Zhang X., Zhao X., Liu Z. In vitro biofilm formation of Gardnerella vaginalis and Escherichia coli associated with bacterial vaginosis and aerobic vaginitis. Front. Cell. Infect. Microbiol. 2024; 14:1387414. https://dx.doi.org/10.3389/fcimb.2024.1387414
23. Giordani B., Naldi M., Croatti V., Parolin C., Erdoğan Ü., Bartolini M. et al. Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms. Microb. Cell. Fact. 2023; 22(1): 45. https://doi.org/10.1186/s12934-023-02053-x
24. Li M., Zeng Z., Wang X., Liu Y., Wei H., Liu J. et al. Mechanisms ofS. agalactiae promoting G. vaginalis biofilm formation leading to recurrence of BV. NPJ Biofilms Microbiomes. 2024; 10(1): 138. https://dx.doi.org/10.1038/s41522-024-00601-w

Поступила 02.04.2026

Принята в печать 03.09.2026