Синцитиотрофобласт ворсин плаценты в норме и при преэклампсии

1. Милованов А.П. Патология системы мать-плацента-плод. М.: Медицина; 1999. 272 с.

2. Щеголев А.И., Павлов К.А., Дубова Е.А., Фролова О.Г. Мертворождаемость в субъектах Российской Федерации в 2010 году. Архив патологии. 2013; 75(2): 20-4.

3. Щеголев А.И., Павлов К.А., Дубова Е.А., Фролова О.Г. Ранняя неонатальная смертность в Российской Федерации в 2010 г. Архив патологии. 2013; 75(4): 15-9.

4. Щеголев А.И., Туманова У.Н., Фролова О.Г. Региональные особенности мертворождаемости в Российской Федерации. В кн.: Актуальные вопросы судебно-медицинской экспертизы и экспертной практики в региональных бюро судебно-медицинской экспертизы на современном этапе. Рязань; 2013: 163-9.

5. Щеголев А.И., Туманова У.Н., Шувалова М.П., Фролова О.Г. Гипоксия как причина мертворождаемости в Российской Федерации. Здоровье, демография, экология финно-угорских народов. 2014; 3: 96-8.

6. Huppertz B. The anatomy of the normal placenta. J. Clin. Pathol. 2008; 61(12): 1296-302. https://dx.doi.org/10.1136/jcp.2008.055277.
7. Aplin J.D. Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidence in vivo and in vitro. J. Cell Sci. 1991; 99(Pt. 4): 681-92.
8. Genbacev O.D., Prakobphol A., Foulk R.A., Krtolica A.R., Ilic D., Singer M.S. et al. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003; 299(5605): 405-8. https://dx.doi.org/10.1126/science.1079546.
9. Huppertz B., Weiss G., Moser G. Trophoblast invasion and oxygenation of the placenta: measurements versus presumptions. J. Reprod. Immunol. 2014; 101-102: 74-9. https://dx.doi.org/10.1016/j.jri.2013.04.003.
10. Salomon C., Kobayashi M., Ashman K., Sobrevia L., Mitchell M.D., Rice G.E. Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes. PLoS One. 2013; 8(11): e79636. https://dx.doi.org/10.1371/journal.pone.0079636.
11. Rodesch F., Simon P., Donner C., Jauniaux E. Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet. Gynecol. 1992; 80(2): 283-5.
12. Jauniaux E., Gulbis B., Burton G.J. Physiological implications of the materno-fetal oxygen gradient in human early pregnancy. Reprod. Biomed. Online. 2003; 7(2): 250-3. https://dx.doi.org/10.1016/s1472-6483(10)61760-9.
13. Lyall F. Mechanisms regulating cytotrophoblast invasion in normal pregnancy and preeclampsia. Aust. N. Z. J. Obstet. Gynaecol. 2006; 46(4): 266-73. https://dx.doi.org/10.1111/j.1479-828X.2006.00589.x.
14. Moser G., Orendi K., Gauster M., Siwetz M., Helige C., Huppertz B. The art of identification of extravillous trophoblast. Placenta. 2011; 32(2): 197-9. https://dx.doi.org/10.1016/j.placenta.2010.11.008.
15. Baines K.J., Renaud S.J. Transcription factors that regulate trophoblast development and function. Prog. Mol. Biol. Transl. Sci. 2017; 145: 39-88. https://dx.doi.org/10.1016/bs.pmbts.2016.12.003.
16. He N., van Iperen L., de Jong D., Szuhai K., Helmerhorst F.M., van der Westerlaken L.A.J. et al. Human extravillous trophoblasts penetrate decidual veins and lymphatics before remodeling spiral arteries during early pregnancy. PLoS One. 2017; 12(1): e0169849. https://dx.doi.org/10.1371/journal.pone.0169849.
17. Chamley L.W., Holland O.J., Chen Q., Viall C.A., Stone P.R., Abumaree M. Review: where is the maternofetal interface? Placenta. 2014; 35(Suppl.): S74-80. https://dx.doi.org/10.1016/j.placenta.2013.10.014.
18. Lunghi L., Ferretti M.E., Medici S., Biondi C., Vesce F. Control of human trophoblast function. Reprod. Biol. Endocrinol. 2007; 5: 6. https://dx.doi.org/10.1186/1477-7827-5-6.
19. Blaise S., de Parseval N., Benit L., Heidmann T. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc. Natl. Acad. Sci. USA. 2003; 100(22): 13013-8. https://dx.doi.org/10.1073/pnas.2132646100.
20. Khong T.Y., Mooney E.E., Nikkels P.G.J., Morgan T.K., Gordinjn S.J., eds. Pathology of the placenta. Springer: Nature Switzerland; 2019. 395p. https://dx.doi.org/10.1007/978-3-319-97214-5.

21. Щеголев А.И. Современная морфологическая классификация повреждений плаценты. Акушерство и гинекология. 2016; 4: 16-23. https://dx.doi.org/10.18565/aig.2016.4.16-23.

22. Fox H., Sebire N.J. Pathology of placenta. 3rd ed. Saunders Elsevier; 2007. 574 p.

23. Щеголев А.И., Серов В.Н. Клиническая значимость поражений плаценты. Акушерство и гинекология. 2019; 3: 54-62. https://dx.doi.org/10.18565/aig.2019.3.54-62.

24. Steegers E.A.P., von Dadelszen P., Duvekot J.J., Pijnenborg R. Pre-eclampsia. Lancet. 2010; 376(9741): 631-44. https://dx.doi.org/10.1016/S0140-6736(10)60279-6.
25. Narasimah A., Vasudeva D.S. Spectrum of changes in placenta in toxemia of pregnancy. Indian J. Pathol. Microbiol. 2011; 54(1): 15-20. https://dx.doi.org/10.4103/0377-4929.77317.
26. Petersen O.M.F., Heller D., Joshi V. Handbook of placental pathology. Oxford: Taylor & Francis; 2006.
27. Guller S. Role of the syncytium in placenta-mediated complications of preeclampsia. Thromb. Res. 2009; 124(4): 389-92. https://dx.doi.org/10.1016/j.thromres.2009.05.016.
28. Ji L., Brkic J., Liu M., Fu G., Peng C., Wang Y.L. Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol. Asp. Med. 2013; 34(5): 981-1023. https://dx.doi.org/10.1016/j.mam.2012.12.008.
29. Sheridan R.M., Stanek J., Khoury J., Handwerger S. Abnormal expression of transcription factor activator protein-2alpha in pathologic placentas. Hum. Pathol. 2012; 43(11): 1866-74. https://dx.doi.org/10.1016/j.humpath.2012.01.011.
30. Sodhi S., Mohan H., Jaiswal T.S., Mohan P.S., Rathee S. Placental pathology in preeclampsia eclampsia syndrome. Indian J. Pathol. Microbiol. 1990; 33(1): 11-6.
31. Daayana S., Baker P., Crocker I. An image analysis technique for the investigation of variations in placental morphology in pregnancies complicated by preeclampsia with and without intrauterine growth restriction. J. Soc. Gynecol. Investig. 2004; 11(8): 545-52. https://dx.doi.org/10.1016/j.jsgi.2004.06.009.
32. Odibo A.O., Zhong Y., Longtine M., Tuuli M., Odibo L., Cahill A.G. et al. First-trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction. Placenta. 2011; 32(4): 333-8. https://dx.doi.org/10.1016/j.placenta.2011.01.016.
33. Shchyogolev A.I., Dubova E.A., Pavlov K.A., Lyapin V.M., Kulikova G.V., Shmakov R.G. Morphometric characteristics of terminal villi of the placenta in pre-eclampsia. Bull. Exp. Biol. Med. 2012; 154(1): 92-5. https://dx.doi.org/10.1007/s10517-012-1883-5.
34. Ishihara N., Matsuo H., Murakoshi H., Laoag-Fernandez J.B., Samoto T., Mauruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am. J. Obstet. Gyneccol. 2002; 186(1): 158-66. https://dx.doi.org/10.1067/mob.2002.119176.
35. Soma H., Yoshida K., Mukaida T., Tabuchi Y. Morphologic changes in the hypertensive placenta. Contrib. Gynecol. Obstet. 1982; 9: 58-75.
36. Jones C.J., Fox H. An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta. 1980; 1(1): 61-76. https://dx.doi.org/10.1016/s0143-4004(80)80016-6.
37. MacLennan A.H., Sharp F., Shaw-Dunn J. The ultrastructure of human trophoblast in spontaneous and induced hypoxia using a system of organ culture. J. Obstet. Gynaecol. Br. Commonw. 1972; 79(2): 113-21.
38. Tenney B., Parker F. The placenta in toxemia of pregnancy. Am. J. Obstet. Gynecol. 1940; 39(6): 1000-5.
39. Sankar K.D., Bhanu P.S., Kiran S., Ramakrishna B.A., Shanthi V. Vasculosyncytial membrane in relation to syncytial knots complicates the placenta in preeclampsia: a histomorphometrical study. Anat. Cell. Biol. 2012; 45(2): 86-91. https://dx.doi.org/10.5115/acb.2012.45.2.86.
40. Fogarty N.M., Ferguson-Smith A.C., Burton G.J. Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage. Am. J. Pathol. 2013; 183(1): 144-52. https://dx.doi.org/10.1016/j.ajpath.2013.03.016.
41. Ogge G., Chaiworapongsa T., Romero R., Hussein Y., Kusanovic J.P., Yeo L. et al. Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia. J. Perinat. Med. 2011; 39: 641-52. https://dx.doi.org/10.1515/JPM.2011.098.
42. Devisme L., Merlot B., Ego A., Houfflin-Debarge V., Deruelle P., Subtil D. A case-control study of placental lesions associated with pre-eclampsia. Int. J. Gynaecol. Obstet. 2013; 120(2): 165-8. https://dx.doi.org/10.1016/j.ijgo.2012.08.023.

43. Щеголев А.И., Ляпин В.М., Туманова У.Н., Воднева Д.Н., Шмаков Р.Г. Гистологические изменения плаценты и васкуляризация ее ворсин при ранней и поздней преэклампсии. Архив патологии. 2016; 78(1): 13-8.

44. Ляпин В.М., Туманова У.Н., Щеголев А.И. Синцитальные узелки в ворсинах плаценты при преэклампсии. Современные проблемы науки и образования. 2015; 4: 499.

45. Salgado S., Salgado M. Structural changes in pre-eclamptic and eclamptic placentas – an ultrastructural study. J. Coll. Physicians Surg. Pak. 2011; 21(8): 482-6.
46. Dimitrovska N. Characteristics of the vasculosyncytial membranes in human chorioplacental villi. Jugosl. Ginekol. Opstet. 1978; 18(3-4): 279-84.

47. Ляпин В.М., Туманова У.Н., Щеголев А.И. Синцитио-капиллярные мембраны в ворсинах плаценты при ранней и поздней преэклампсии. Современные проблемы науки и образования. 2015; 5: 295.

48. Колобов А.В. Место ретровирусов в перинатальной патологии (обзор литературы). Журнал инфектологии. 2012; 4(4): 13-9.

49. Noorali S., Rotar I.C., Lewis C., Pestaner J.P., Pace D.G., Sison A. Role of HERV-W syncytin-1 in placentation and maintenance of human pregnancy. Appl. Immunohistochem. Mol. Morphol. 2009; 17(4): 319-28. https://dx.doi.org/10.1097/PAI.0b013e31819640f9.
50. Langbein M., Strick R., Strissel P.L., Vogt N., Parsch H., Beckman M.W. et al. Impaired cytotrophoblast cell–cell fusion is associated with reduced syncytin and increased apoptosis in patients with placental dysfunction. Mol. Reprod. Dev. 2008; 75(1): 175-83. https://dx.doi.org/10.1002/mrd.20729.
51. Huang Q., Chen H., Li J., Oliver M., Ma X., Byck D. et al. Epigenetic and non-epigenetic regulation of syncytin-1 expression in human placenta and carrier tissues. Cell. Signal. 2013; 26(3): 648-56. https://dx.doi.org/10.1016/j.cellsig.2013.11.002.
52. Lee X., Keith J.C. Jr., Stumm N., Moutsatsos I., McCoy J.M., Crum C.P. et al. Downregulation of placental syncytin expression and abnormal protein localization in pre-eclampsia. Placenta. 2001; 22(10): 808-12. https://dx.doi.org/10.1053/plac.2001.0722.
53. Huang Q., Chen H., Wang F., Brost B.C., Li J., Gao Y. et al. Reduced syncytin-1 expression in choriocarcinoma BeWo cells activates the calpain1-AIF-mediated apoptosis, implication for preeclampsia. Cell. Mol. Life Sci. 2014; 71(16): 3151-65. https://dx.doi.org/10.1007/s00018-013-1533-8.
54. Tolosa J.M., Schjenken J.E., Clifton V.L., Vargas A., Barbeau B., Lowry P. et al. The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. Placenta. 2012; 33(11): 933-41. https://dx.doi.org/10.1016/j.placenta.2012.08.004.
55. Chaiworapongsa T., Romero R., Yoshimatsu J., Espinoza J., Kim Y.M., Park K. et al. Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia. J. Matern. Fetal Neonatal Med. 2002; 12: 19-27. https://dx.doi.org/10.1080/jmf.12.1.19.27.
56. Koga K., Osuga Y., Yoshino O., Hirota Y., Ruimeng X., Hirata T. et al. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J. Clin. Endocrinol. Metab. 2003; 88(5): 2348-51. https://dx.doi.org/10.1210/jc.2002-021942.
57. Tripathi R., Rath G., Ralhan R., Saxena S., Salhan S. Soluble and membranous vascular endothelial growth factor receptor-2 in pregnancies complicated by pre-eclampsia. Yonsei Med. J. 2009; 50(5): 656-66. https://dx.doi.org/10.3349/ymj.2009.50.5.656.
58. Dubova E.A., Pavlov K.A., Lyapin V.M., Shchyogolev A.I., Sukhikh G.T. Vascular endothelial growth factor and its receptors in the placental villi of pregnant patients with pre-eclampsia. Bull. Exp. Biol. Med. 2013; 154(6): 792-5. https://dx.doi.org/10.1007/s10517-013-2058-8.
59. Sukhikh G.T., Ziganshina M.M., Nizyaeva N.V., Kulikova G.V., Volkova J.S., Yarotskaya E.L., Kan N.E., Shchyogolev A.I., Tyutyunnik V.L. Differences of glycocalyx composition in the structural elements of placenta in preeclampsia. Placenta. 2016; 43: 69-76. https://dx.doi.org/10.1016/j.placenta.2016.05.002.

Поступила 15.01.2020

Принята 07.02.2020