Внеклеточные везикулы, полученные из мультипотентных мезенхимальных стромальных клеток: патогенетическое обоснование терапевтического применения

DOI

https://dx.doi.org/10.18565/aig.2023.239

Мартиросян Я.О., Кадаева А.И., Силачев Д.Н., Назаренко Т.А., Матвеева П.В.
ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской Федерации, Москва, Россия

Представленный обзор научных исследований является продолжением обсуждения современных взглядов на фолликулогенез и его регуляцию.
В нем мы попытались описать возможности и перспективы применения клеточной терапии в репродуктивной медицине, а также возможные механизмы влияния стволовых клеток и их внеклеточных везикул на механизмы рекрутирования фолликулов. Перспективы применения таргетных агентов в терапии преждевременной недостаточности яичников объясняются тем фактом, что большинство примордиальных фолликулов яичников в течение всей жизни женщины остаются в спящем, неактивном состоянии. Экспериментальные исследования позволили установить основные сигнальные пути, участвующие в регуляции раннего фолликуло- и оогенеза. Изучение регуляции активности ключевых сигнальных путей позволит разработать таргеты для дальнейшего влияния на гонадотропин-независимую фазу роста фолликулов и, возможно, преодолеть такие грубые нарушения репродуктивной системы, как преждевременная недостаточность яичников и возраст-ассоциированное снижение качества и количества ооцитов.
Проведен анализ литературных данных и описаны возможные механизмы влияния клеточной терапии на состояние овариального резерва.
В обзор включены данные зарубежных статей, опубликованных в базах eLibrary.ru и PubMed по данной теме.
Заключение: Представленная информация о путях воздействия внеклеточных везикул раскрывает перспективы лечения бесплодия у сложной категории пациенток. Дальнейшие исследования механизмов функционирования, точек приложения внеклеточных везикул необходимы для расширения терапевтических возможностей.

Вклад авторов: Мартиросян Я.О., Кадаева А.И., Силачев Д.Н., Назаренко Т.А., Матвеева П.В. – разработка дизайна исследования, получение данных для анализа, обзор публикаций по теме статьи, анализ полученных данных, написание текста рукописи.
Конфликт интересов: Авторы заявляют об отсутствии возможных конфликтов интересов.
Финансирование: Работа выполнена в рамках государственного задания 22-А21 Назаренко Т.А. «Решение проблемы бесплодия в современных условиях путем разработки клинико-диагностической модели бесплодного брака и использования инновационных технологий в программах вспомогательной репродукции».
Для цитирования: Мартиросян Я.О., Кадаева А.И., Силачев Д.Н., Назаренко Т.А., Матвеева П.В. Внеклеточные везикулы, полученные из мультипотентных мезенхимальных стромальных клеток: патогенетическое обоснование терапевтического применения.
Акушерство и гинекология. 2024; 1: 26-33
https://dx.doi.org/10.18565/aig.2023.239

сниженный овариальный резерв

преждевременная недостаточность яичников

внеклеточные везикулы

ЭКО

ЭКО/ИКСИ

внутрияичниковое введение

мультипотентные мезенхимальные стромальные клетки

Полный текст статьи
доступен в "Библиотеке Врача"

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Поступила 16.10.2023

Принята в печать 09.01.2024

Received 16.10.2023

Accepted 09.01.2024

De Vos M., Devroey P., Fauser B.C. Primary ovarian insufficiency. Lancet. 2010; 376(9744): 911-21. https://dx.doi.org/10.1016/S0140-6736(10)60355-8.
Golezar S., Ramezani Tehrani F., Khazaei S., Ebadi A., Keshavarz Z. The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis. Climacteric. 2019; 22(4): 403-11. https://dx.doi.org/10.1080/13697137.2019.1574738.
Sydsjö G., Bladh M., Rindeborn K., Hammar M., Rodriguez-Martinez H.,Nedstrand E. Being born preterm or with low weight implies a risk of infertility and premature loss of ovarian function; a national register study. Ups. J. Med. Sci. 2020; 125(3): 235-9. https:/dx.doi.org/10.1080/03009734.2020.1770380.
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Поступила 16.10.2023

Принята в печать 09.01.2024

Мартиросян Яна Ованнесовна, к.м.н., врач акушер-гинеколог НКО ВРТ им. Ф. Паулсена, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Министерства здравоохранения Российской Федерации, +7(925)124-99-99, marti-yana@yandex.ru,
117997, Россия, Москва, ул. Академика Опарина, д. 4.
Кадаева Альбина Ильдаровна, аспирант по специальности «акушерство-гинекология», Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Министерства здравоохранения Российской Федерации, +7(917)762-82-11, albina.karimovai@mail.ru,
117997, Россия, Москва, ул. Академика Опарина, д. 4.
Силачев Денис Николаевич, д.б.н., руководитель лаборатории клеточных технологий, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Министерства здравоохранения Российской Федерации, silachevdn@genebee.msu.ru,
117997, Россия, Москва, ул. Академика Опарина, д. 4.
Назаренко Татьяна Алексеевна, профессор, д.м.н., директор института репродуктивной медицины, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Министерства здравоохранения Российской Федерации, +7(495)531-44-44, t_nazarenko@oparina4.ru,
117997, Россия, Москва, ул. Академика Опарина, д. 4.
Матвеева Полина Владимировна, студент, Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации, +7(985)974-74-51, polina.matveeva00@gmail.ru, 119048, Россия, Москва, ул. Трубецкая, д. 8, стр. 2.

Внеклеточные везикулы, полученные из мультипотентных мезенхимальных стромальных клеток: патогенетическое обоснование терапевтического применения

Мартиросян Я.О., Кадаева А.И., Силачев Д.Н., Назаренко Т.А., Матвеева П.В.

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